Integrin Receptor Imaging 99mTc-3PRGD2 SPECT/CT in Diagnosis and Lymph Node Staging of Non-Small Cell Lung Cancer
10.3969/j.issn.1674-9081.2016.05.002
- VernacularTitle:整合素受体显像99m Tc-3PRGD2 SPECT/CT用于非小细胞肺癌诊断及淋巴结分期的价值
- Author:
Xiao-Na JIN
1
;
Nai-Xin LIANG
;
Meng-Zhao WANG
;
Bing JIA
;
Xi-Min SHI
;
Shan-Qing LI
;
Fang LI
;
Fan WANG
;
Zhao-Hui ZHU
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院核医学科
- Keywords:
integrinαvβ3;
single photon emission computed tomography;
non-small cell lung cancer;
lymph node metastasis
- From:
Medical Journal of Peking Union Medical College Hospital
2016;7(5):327-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prospectively evaluate the value of integrinαvβ3 receptor imaging approach based on single photon emission computed tomography/computed tomography(SPECT/CT),using 99mTc-3PRGD2 as the tracer,in diagnosis and staging of non-small cell lung cancer( NSCLC)compared with 18 F-FDG positron emisson tomography/computed tomography( PET/CT). Methods From February 2011 to December 2012 , 65 patients with suspicious lung lesions were recruited with informed consent in Peking Union Medical Col-lege Hospital,including 41 males and 24 females,with a mean age of(60 ± 11)years. The patients under-went both 99mTc-3PRGD2 SPECT/CT and 18F-FDG PET/CT within one week. After pathological diagnosis, all the patients were followed up until death or for at least two years. Receiver operating characteristic ( ROC)curve,Z test,and Chi-square test were used to compare the diagnostic performance of the two ima-ging methods in assessing lung lesions and mediastinal lymph nodes. Results Sixty-five lung lesions in 53 patients were pathologically diagnosed as NSCLC,and 14 lung lesions in 12 patients were proved as benign. Based on the American Joint Committee on Cancer/Union for International Cancer Control( AJCC-UICC)stand-ard,248 regions of lymph nodes had metastasis and 56 were negative regions. 99m Tc-3PRGD2 SPECT/CT was found to have higher specificity compared with 18 F-FDG PET/CT in the per-region diagnosis of lymph node metas-tasis(94. 6% vs. 75. 0%,P=0. 008),whereas the sensitivity of the two methods showed no statistically signifi-cant difference(88. 3% vs. 90. 7%,P=0. 557). There was no significant difference between the two methods in diagnostic performance for lung lesion( Z =0. 82 ,P =0. 410 ). Conclusion 99m Tc-3PRGD2 SPECT/CT shows high specificity in the diagnosis of lymph node metastasis from NSCLC,which may complement 18 F-FDG PET/CT in diagnosis and benefit surgical decision-making for patients with lung cancer.
