Effect of early enteral nutrition support on nutritional status and infection complications in patients with severe craniocerebral injury: a Meta-analysis
10.3760/cma.j.issn.1674-2907.2019.29.012
- VernacularTitle:早期肠内营养支持对颅脑损伤患者营养状况及感染并发症影响的Meta分析
- Author:
Yanmei SHI
1
;
Quancheng ZHANG
;
Hongle ZHAO
;
Meng LYU
;
Lingyu DAI
;
Shuxiang ZHANG
Author Information
1. 山东第一医科大学第一附属医院(山东省千佛山医院)消化内科
- Keywords:
Severe craniocerebral injury;
Nutritional status;
Infection;
Early enteral nutrition;
Delayed enteral nutrition;
Meta-analysis
- From:
Chinese Journal of Modern Nursing
2019;25(29):3765-3770
- CountryChina
- Language:Chinese
-
Abstract:
Objective? To evaluate the impacts of early enteral nutrition (EEN) support and delayed enteral nutrition(DEN) support in the nutritional status and infection complications in patients with severe traumatic brain injury. Methods? The articles of randomized controlled trials about EEN support and DEN support on the nutritional status and infection complications in patients with severe traumatic brain injury were searched in CBMdisc, CNKI, Wanfang Data, VIP, Cochrane Library, Web of Science, PubMed, EMbase from 1990 to 2017. The quality evaluation method in Cochrane-Handbook5.0 handbook was adopted to evaluate the quality of articles and test the heterogeneity of the included articles. Fixed-effect model or random-effect model were used to merge the effects. Results? A total of 10 randomized controlled trials were included. Meta-analysis results proved that, compared with DEN support, EEN support can increase the level of serum total protein, albumin and peripheral lymphocyte count (Z=10.20, 4.23, 5.24;P＜0.01) and reduce the incidence of pulmonary infection and craniocerebral infection in patients with craniocerebral injury (Z=4.12, 2.15; P＜0.05), but it has no effect on the incidence of upper gastrointestinal hemorrhage in patients with craniocerebral injury (Z=0.82, P=0.41). Conclusions? Compared with DEN support (within 48 hours of admission), EEN support (48 hours after admission) can effectively improve serum total protein and albumin, improve nutritional status, increase peripheral lymphocyte count, increase patient resistance and reduce the occurrence of cranial infection and pulmonary infection. Therefore, patients with severe craniocerebral injury should receive EEN support if there is no contraindication.
