Changes of Hormone Levels and Ovary Size in Ovarian Aging
10.3969/j.issn.1674-9081.2016.03.001
- VernacularTitle:卵巢衰老过程中血清性激素和卵巢大小的变化
- Author:
Ya-Ping WANG
1
;
Rong CHEN
;
Shou-Qing LIN
;
Jing-Lan BAI
;
Yan-Yan FAN
;
Hui-Jun LIN
;
Ying ZHANG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院妇产科
- Keywords:
STRAW+10 staging system;
estradiol;
follicle stimulating hormone;
ovarian size
- From:
Medical Journal of Peking Union Medical College Hospital
2016;7(3):161-167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum sex hormone levels and ovary size in ovarian aging in women living in a Beijing community .Methods A total of 418 healthy women aged 30 to 68 years who could be staged by STRAW +10 staging system were recruited from a Beijing community and prospectively fol -lowed-up for 5 years.Menstrual diary was recorded by every woman during the research .Serum estradiol ( E2 ) and follicle stimulating hormone ( FSH) levels were tested at baseline and 5 years later .Pelvic ultrasonography was performed for measurement of ovary size .Results According to STRAW+10 stage, E2 began to decrease in early postmenopausal stage , which further decreased in late postmenopausal stage .FSH increased significantly from the beginning of late menopausal transition stage , remaining at a high level after menopause .The length , width , and area of the ovary all reduced after menopause .Hormone levels and ovary size changed with some rules in the 5-year follow-up even when the STRAW+10 stage did not change .In women with staging progressed after 5 years of follow-up, E2 and FSH levels, and length, width, and area of the ovary were significantly different ( all P<0.01 ) when progressing from early or late menopausal transition stage to early postmenopausal stage . Ovarian no-echo cyst (diameter ≥1.4 cm and <2.5 cm) was the most common in late menopausal transition stage both at baseline and after 5 years, with an incidence of 6.5% and 12.1%, respectively.Conclusions When the STRAW+10 stage changes from menopausal transition to early postmenopausal stage , E2 decreases and FSH increases significantly with obvious ovarian atrophy .Reproductive aging has more influence on hormone lev-els and ovary size than aging does .STRAW+10 staging system could be applied for women in Beijing .
