Clinicopathological Features and Immunohistochemical Phenotypes of Adenoid Cystic Carcinoma of the Uterine Cervix
10.3969/j.issn.1674-9081.2015.03.007
- VernacularTitle:宫颈腺样囊性癌临床病理特征及免疫组织化学表型
- Author:
Xiao-Hua SHI
1
;
Sha-Fei WU
;
Qing LING
;
Zhen HUO
;
Zhi-Yong LIANG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院病理科
- Keywords:
cervix;
adenoid cystic carcinoma;
immunohistochemistry;
differential diagnosis;
C-MYB
- From:
Medical Journal of Peking Union Medical College Hospital
2015;(3):197-201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological and immunohistochemical features of adenoid cystic carcinoma ( ACC) of the uterine cervix .Methods Four cases who were diagnozed with ACC of the uter-ine cervix in the period from January 2003 to December 2013 were collected from the pathological databank and consultation database of Peking Union Medical Hospital .Immunohistochemical examination was conducted on the formalin-fixed, paraffin-embedded tissue specimens from the 4 patients.Clinical information, pathological fea-tures, treatment, and outcomes of these patients were summarized .Results The average age of the 4 ACC patients was 61.5 years.The patients were mostly post-menopausal (3/4) and their chief complaint was vaginal bleeding (3/4).The tumors were primarily protruding masses (3/4).Histologically, 3 of the 4 cases were ACC combined with invasive squamous cell carcinoma , the other 1 was ACC alone .The growth pattern of ACC in all of the 4 ca-ses was cribriform composed of luminal adenoepithelial and abluminal myoepithelial cells .Immunohistochemical findings supported the identification of 2 components in ACC:positive expression of CK 7 in luminal adenoepithe-lial cells, and positive expressions of P 63 and SMA in abluminal myoepithelial cells .C-MYB, a ACC-specific marker, was found with strong positive expression in all the 4 cases.Three of the 4 patients had total hysterecto-my, the other 1 had conization .All were in stage I in terms of clinical staging .Postoperative radiotherapy was ad-ministered in all the 4 cases, combined with chemotherapy in 2.The mean follow-up period was 21.25 months, finding all the 4 patients in disease-free survival .Conclusions ACC of the uterine cervix is a rare special type of adenocarcinoma , usually coexisting with other types of cervical tumors .The immunohistochemical findings in ACC of the uterine cervix are similar with ACC in other organs , but associated with poorer prognosis .Radiotherapy and chemotherapy after sugery is recommended .Early detection and treatment could improve survival .
