Clinicopathological Features and Epidermal Growth Factor Receptor Gene Status of Adrenocortical Oncocytic Carcinoma
10.3969/j.issn.1674-9081.2015.03.006
- VernacularTitle:肾上腺嗜酸细胞型皮质癌的临床病理特征及表皮生长因子受体基因状态
- Author:
Jing ZHANG
1
;
Jie GAO
;
Sha-Fei WU
;
Tao LU
;
Zhi-Yong LIANG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院病理科
- Keywords:
adrenocortical oncocytic carcinoma;
epidermal growth factor receptor;
immunohistochemistry;
fluorescence in situ hybridization;
gene mutation
- From:
Medical Journal of Peking Union Medical College Hospital
2015;(3):191-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinicopathological features of adrenocortical oncocytic carcinoma and protein expression , gene mutation , and gene copy number alteration of epidermal growth factor receptor ( EGFR) in this carcinoma .Methods We reviewed the clinical and histomorphological features of 9 adrenocorti-cal oncocytic carcinoma cases who received surgical resection in the period of January 2000 to December 2009 in Peking Union Medical College Hospital , and 9 adenoma cases were included as control .EGFR protein expres-sion , EGFR gene mutation and EGFR gene copy number alteration in both groups were detected by immunohisto -chemistry , Scorpion Amplification Refractory Mutation System ( ARMS ) , and fluorescence in situ hybridization ( FISH) , respectively . Results The 9 cases of adrenocortical oncocytic carcinomas included 2 cases of Cushing's syndrome and 7 cases of nonfunctional cortical carcinoma .All cases were followed up for 6 to 56 months, and 2 patients with adrenocortical oncocytic carcinomas lost to follow -up, and 6 died.In the adrenocorti-cal oncocytic carcinoma patients , EGFR overexpression was found in 77.8%(7/9), and EGFR FISH was posi-tive in 55.6%(5/9).In contrast, only 22.2% (2/9) of the adrenocortical adenoma patients showed EGFR weak expression and none had positive FISH result .No EGFR gene amplification or mutation was found in the 2 groups of patients .Conclusions Adrenocortical oncocytic carcinoma is rare .EGFR overexpression and chromo-some 7 polysomy are frequent abnormality in the adrenocortical oncocytic carcinomas , which may be used in the differential diagnosis .Also, an investigation of the gene status of EGFR should facilitate the identification of a target therapeutic regimen for carcinoma patients .
