Clinical characteristics of myeloid tumors combined with the proliferation of large granular lymphocytes

VernacularTitle:髓系肿瘤伴大颗粒淋巴细胞增殖的临床特征研究
Author: Chenxiao DU ¹ ; Guangpeng XIANG ; Lan PENG ; Xiangyao XIAO ; Guangshuai TENG ; Yuhui ZHANG ; Yan WANG ; Yifan DUAN ; Zonghong SHAO ; Jie BAI
Author Information

1. 天津医科大学第二医院血液科，天津　300211
From: Chinese Journal of Hematology 2024;45(4):396-400
CountryChina
Language:Chinese
Abstract: Myeloid neoplasms (MNs) belong to a group of hematological malignancies characterized by the abnormal biological functions of hematopoietic stem progenitor cells. The abnormal immune and hematopoietic microenvironment of patients with MN interact with malignant clonal hematopoietic stem cells, promoting the occurrence and development of their diseases. MN large granular lymphocyte proliferation (MN-LGLP) is a special and rare clinical phenomenon in this type of disease. Currently, research on this disease in domestic and international cohorts is limited. This study analyzes the clinical and laboratory characteristics of this type of patient and explores the impact of LGLP on the clinical characteristics and survival of patients with MN. Patients with MN-LGLP are prone to neutropenia and splenomegaly. The presence of LGLP is not a risk factor affecting the survival of patients with MN-LGLP. STAG, ASXL1, and TET2 are the most common accompanying gene mutations in MN-LGLP, and patients with MN-LGLP and STAG2 mutations have poor prognoses.