Demographic Features, Etiology Trend and Clinical Characteristics of Chronic Pancreatitis:A Respective Study of 346 Cases in Peking Union Medical College Hospital
10.3969/j.issn.1674-9081.2015.02.003
- VernacularTitle:北京协和医院346例慢性胰腺炎人口学特征、病因变迁及临床特点
- Author:
Ya-Min LAI
1
;
Tao GUO
;
Hui DING
;
LHong
;
Hong YANG
;
Ai-Ming YANG
;
Jing-Nan LI
;
Ting WEI
;
Hui WANG
;
Yue ZHANG
;
Jia-Ming QIAN
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院消化内科
- Keywords:
chronic pancreatitis;
epidemiology;
alcoholic chronic pancreatitis;
biliary chronic pancreatitis;
autoimmune pan-creatitis
- From:
Medical Journal of Peking Union Medical College Hospital
2015;(2):89-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the demographic features, etiology and clinical characteristics of chro-nic pancreatitis ( CP) .Methods We retrospectively analyzed the records of 346 CP cases hospitalized in Peking Union Medical College Hospital during the period of January 1983 to December 2008, summarizing the demographic features, clinical manifestations, causes of disease, and complications of these patients.Results The 346 CP ca-ses included 267 males and 79 females ( M/F ratio=3.38∶1 ) .The mean age of onset was ( 44.34 ±15.88 ) years.Most of the patients were Han Chinese ( 94.80%, 328/346 ) , and a large proportion were cadres (32.08%, 111/346) .Both the number of CP cases and its proportion in the total number of inpatients in the hospital increased rapidly.Alcohol (40.17%) and cholelithiasis (41.04%) were the most common risk factors of CP.CP of different etiologies had all increased, especially alcoholic CP, growing by an mean annual rate of 108.7%.84.39% (292/346) of the patients presented with abdominal pain, 56.07%(194/346) had weight loss, 24.86%(86/346) had jaundice (all obstructive).Diabetes (25.14%, 87/346) was the most common complication.The median time of CP onset to occurrence of diabetes and fatty diarrhea were 1.00 year and 280.03 months, respectively.Diabetes occurred earlier in patients with autoimmune pancreatitis than those with idiopathic pancreatitis (P=0.020).Conclusions The incidence of CP is growing rapidly in China, with alco-holic CP increasing faster than biliary CP.The most common symptoms of CP are abdominal pain and weight loss, while the most common complication is diabetes.A patient database and regular follow-up visits could contribute to better understanding of epidemiological patterns of CP and improvement of its diagnosis and treatment.
