Detection of cytogenetic abnormalities in multiple myeloma by using optical genome mapping
10.3760/cma.j.cn121090-20230915-00123
- VernacularTitle:利用全基因组光学图谱检测多发性骨髓瘤细胞遗传学异常
- Author:
Yanfang WANG
1
;
Zhenhao ZHANG
;
Hua WANG
;
Lianyong XI
;
Fei DONG
;
Hongmei JING
Author Information
1. 北京大学第三医院血液内科，北京 100191
- From:
Chinese Journal of Hematology
2024;45(3):303-307
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma (MM) is a plasma cell neoplasm characterized by numerous chromosomal number and structural abnormalities, which are of great significance for risk stratification and response evaluation of MM patients. Optical genome mapping (OGM) is a novel technology that has the potential to resolve many of the issues and limitations associated with traditional cytogenetic methods. To date, the clinical utility of OGM has been validated in the fields of cancer, reproduction, and embryonic dysplasia, et al. In this study, we compared OGM to traditional techniques for the first time in five newly diagnosed MM patients, and evaluated the potential of OGM for detecting cytogenetic aberrations and its clinical application value in MM.
