Application of Gingival and Tongue Biopsy in Diagnosis of Amyloidosis
10.3969/j.issn.1674-9081.2014.04.018
- VernacularTitle:牙龈和舌组织活检在淀粉样变性病诊断中的应用和比较
- Author:
XüGang
1
;
De-Shun DU
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院口腔科
- Keywords:
amyloidosis;
gingival;
tongue;
biopsy
- From:
Medical Journal of Peking Union Medical College Hospital
2014;(4):441-444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate and compare the diagnostic values of gingival and tongue biopsies in amyloidosis .Methods We retrospectively analyzed the clinical data of 32 amyloidosis patients who underwent gingival and tongue biopsies in Department of Stomatology of Peking Union Medical College Hospital from May 2012 to July 2013.Among them, 24 patients received abdominal fat biopsy in Department of General Surgery in the same period .Specimens were sliced in routine process , followed by staining with HE and Congo red .Results On light microscopy , amyloidosis was demonstrated as pink stains in HE staining , brick red in Congo red stai-ning, and in polarized light , apple-green birefringent deposits .Gingival biopsy was positive in 22 cases, tongue biopsy in 23 cases, and abdominal fat biopsy in 19 cases.In total, 29 amyloidosis cases were confirmed by gingi-val and tongue biopsies ( positive rate 90.63%) .Chi-squared test revealed no statistically significant difference between gingival biopsy and tongue biopsy in detecting amyloidosis ( P >0.05 ) .Conclusion Gingival and tongue biopsies can both provide solid diagnostic evidence in amyloidosis .
