Dosimetric Comparison of Different Pattern of Intensity-modulated Radiotherapy for Pancreatic Carcinoma
10.3969/j.issn.1674-9081.2014.04.013
- VernacularTitle:胰腺癌不同调强方式的剂量学比较
- Author:
Wei-Ping WANG
1
;
Bo YANG
;
Ting-Tian PANG
;
Nan LIU
;
Ke HU
;
Jie QIU
;
Fu-Quan ZHANG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院放射治疗科
- Keywords:
pancreatic carcinoma;
radiotherapy;
fixed-field intensity-modulated radiotherapy;
volumetric modulated arc therapy
- From:
Medical Journal of Peking Union Medical College Hospital
2014;(4):417-421
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the dosimetric differences between fixed-field intensity-modulated ra-diotherapy ( FF-IMRT) and volumetric modulated arc therapy ( VMAT) in treating pancreatic carcinoma , aiming to facilitate the clinical decision upon appropriate radiation technique .Methods From June to December 2011 , 10 postoperative patients of pancreatic carcinoma who received radiotherapy in Peking Union Medical College Hos -pital were selected for this comparison .FF-IMRT and VMAT plans were developed based on the same CT simula-tion image for each patient .The prescription dose was 50 Gy in 25 fractions.The doses distributions in planning target volume (PTV), organs at risk (OARs), and normal tissue were evaluated based on dose-volume histo-grams ( DVH) .The two plans were also compared in terms of monitor unit ( MU ) and length of treatment . Results The dose distributions in PTV showed no significant difference between FF-IMRT and VMAT plans (P>0.05).Compared with FF-IMRT plan, VMAT plan significantly increased V 5 of the liver, stomach, small intestine, and whole body (all P<0.05), while reduced V10 and V20 of the liver, V10 of the stomach, V10, V20 , and V50 of the small intestine , V20 of the left kidney , V20 , V30 , Dmean , Dmax of the right kidney , and V10 , V20 of the whole body (all P<0.05).The Dmax of the spinal cord decreased by 1.85 Gy in VMAT plan (P=0.04 ) .MU of VMAT plan was significantly lower than that of FF-IMRT plan ( 492.70 ±51.56 vs.619 ± 117.18 , t=3.18 , P=0.01 ) , with a 20.48%reduction from the MU level of the latter one .Conclusion For patients with pancreatic carcinoma , VMAT plan could reduce MU and shorten length of treatment while maintai-ning the dosimetric parameters at levels similar to or even better than those of FF -IMRT plan.
