Primary Intramedullary Spinal Cord Mixed Germinoma in Children:Report of One Case and Review of Literature
10.3969/j.issn.1674-9081.2014.04.008
- VernacularTitle:儿童原发性脊髓混合性生殖细胞瘤1例及文献复习
- Author:
Xue-Zhen ZHAO
1
;
Juan XIAO
;
Li-Juan GOU
;
Ji LI
;
Ming-Ming HU
;
Ming LI
;
Chang-Yan WANG
;
Chen WANG
;
Lin WANG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院 1 儿科
- Keywords:
spinal cord;
mixed germinoma;
children
- From:
Medical Journal of Peking Union Medical College Hospital
2014;(4):393-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features, diagnosis, treatment and prognosis of prima-ry intramedullary spinal cord germinoma ( PISCG) in children.Methods One child with primary intramedul-lary spinal cord mixed germinoma was reported in this article .To our knowledge , there has been no previous report of such cases at home and abroad .The related literature of PISCG was reviewed and analyzed .Results The clinical manifestations of the 5-year-old boy included the progression of hip pain and precocious puberty . Alpha-fetoprotein ( AFP) andβ-human chorionic gonadotrophin (β-HCG ) levels elevated obviously in serum and cerebrospinal fluid .Magnetic resonance imaging ( MRI) demonstrated an intraspinal mass extending from L2 to L3.Histopathological examination showed mixed germinoma (germinoma and teratoma).18F-fluorodeoxy-glucose positron emission tomography (18F-FDG-PET) was applied to help displaying the lesion, evaluating therapeutic effect and monitoring recurrence via the maximum standardized uptake value ( SUVmax) .The child responded poor to radiotherapy , while fair to chemotherapy .Conclusions PISCG in children is extremely rare.Its clinical manifestations are consistent with the involved segments of the spinal cord and should be dif-ferentiated from other primary tumors in spinal cord .Simple PISCG in children is sensitive to radiotherapy and chemotherapy , with generally favorable prognosis .
