Biological characteristics and clinical significance of stereotyped B-cell receptor in chronic lymphocytic leukemia
10.3760/cma.j.cn121090-20230718-00012
- VernacularTitle:慢性淋巴细胞白血病中B细胞受体同型模式的生物学特征和临床意义
- Author:
Tonglu QIU
1
;
Jianyong LI
;
Yi XIA
Author Information
1. 南京医科大学第一附属医院，江苏省人民医院血液科，南京医科大学血液研究重点实验室，江苏省肿瘤个体化医学协同创新中心，南京 210029
- From:
Chinese Journal of Hematology
2024;45(2):197-202
- CountryChina
- Language:Chinese
-
Abstract:
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western adults, although the incidence of CLL is relatively low in Asian populations. However, with the aging population, the incidence of CLL is increasing in China. The interaction between CLL cells and the microenvironment plays a crucial role in the recognition of antigens by the B-cell receptor immunoglobulin (BCR IG). The mutational status of the immunoglobulin heavy variable region (IGHV) is a classical prognostic marker for CLL. Over 40% of CLL patients exhibit biased usage of IGHV and highly similar amino acid sequences in the heavy complementarity-determining region 3 (HCDR3), known as the BCR stereotypy. Different subgroups of stereotyped BCR exhibit distinct biological and clinical features. Among them, subset #2 with mutated IGHV and poor prognosis, as well as the subset #8 with a high risk of Richter transformation, have been recommended by the European Research Initiative on CLL to be included in clinical reports on IGHV mutational status. This review summarizes the definition, distribution, biological characteristics, and clinical significance of clonality patterns of the BCR in CLL.
