Evaluation of the efficacy and safety of intravenous infusion of ferric derisomaltose in the treatment of iron deficiency anemia: a single-center retrospective analysis
10.3760/cma.j.cn121090-20230718-00009
- VernacularTitle:静脉滴注异麦芽糖酐铁治疗缺铁性贫血的疗效及安全性评估：单中心回顾性分析
- Author:
Shaoxue DING
1
;
Yihui ZHAO
;
Ting WANG
;
Jing GUAN
;
Limin XING
;
Hong LIU
;
Guojin WANG
;
Xiaoming WANG
;
Yuhong WU
;
Wen QU
;
Jia SONG
;
Huaquan WANG
;
Lijuan LI
;
Zonghong SHAO
;
Rong FU
Author Information
1. 天津医科大学总医院血液内科，天津市骨髓衰竭及癌性造血克隆防治重点实验室，天津 300052
- Keywords:
Iron deficiency anemia;
Intravenous ferric derisomaltose;
Intravenous iron sucrose
- From:
Chinese Journal of Hematology
2024;45(2):178-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy and safety of ferric derisomaltose injection versus iron sucrose injection in the treatment of iron deficiency anemia (IDA) .Methods:A total of 120 patients with iron deficiency anemia admitted from June 2021 to March 2023 were given intravenous iron supplementation with ferric derisomaltose to assess the efficacy and safety of hemoglobin (HGB) elevation before and after treatment. Simultaneously, the clinical effects of iron supplementation with iron sucrose were compared to those of inpatient patients during the same period.Results:Baseline values were comparable in both groups. Within 12 weeks of treatment, the elevated HGB level in the ferric derisomaltose group was higher than that of the iron sucrose group, with a statistical difference at all time points, and the proportion of HGB increased over 20 g/L in the patients treated for 4 weeks was higher (98.7%, 75.9% ). During the treatment with ferric derisomaltose and iron sucrose, the proportion of mild adverse reactions in the ferric derisomaltose group was slightly lower than that of the iron sucrose group, and neither group experienced any serious adverse reactions. The patients responded well to the infusion treatment, with no reports of pain or pigmentation at the injection site.Conclusion:The treatment of IDA patients with ferric derisomaltose has a satisfactory curative effect, with the advantages of rapidity, accuracy, and safety. Therefore, it is worthy of widespread clinical use.
