Different Expressions of Bcl-2 and Vascular Endothelial Growth Factor Receptor-3 in Intravenous Leiomyomatosis and Classical Leiomyoma
10.3969/j.issn.1674-9081.2014.03.010
- VernacularTitle:Bcl-2和血管内皮生长因子受体3在子宫静脉内平滑肌瘤病与普通型平滑肌瘤中的表达差异
- Author:
Wen-Ze WANG
1
;
Guo-Tao MA
;
Yu XIAO
;
Zhi-Yong LIANG
;
Wei-Zhen LOU
;
Ji LI
;
Da-Chun ZHAO
;
Huan-Wen WU
;
Tong-Hua LIU
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院 病理科
- Keywords:
intravenous leiomyomatosis;
bcl-2;
vascular endothelial growth factor receptor-3;
immunohistochemistry
- From:
Medical Journal of Peking Union Medical College Hospital
2014;(3):297-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the different expressions of bcl-2 and vascular endothelial growth factor receptor-3 (VEGFR-3) in intravenous leiomyomatosis (IVL) and classical leiomyoma (LM).Methods We retro-spectively reviewed the pathology of 20 cases of IVL , matching with 10 cases of LM.The bcl-2 and VEGFR-3 im-munohistochemical staining was performed in the slides from all cases , and the results were compared between the IVL group and LM group .Results In the IVL group , all the 20 cases showed moderate to strong bcl-2 immunohis-tochemical staining .Meanwhile, 19 cases showed moderate to strong VEGFR-3 immunohistochemical staining , while 1 case was negative .In the LM group , all 10 cases showed weak to moderate bcl-2 immunohistochemical stai-ning and negative VEGFR-3 staining.Conclusions Both bcl-2 and VEGFR-3 are highly expressed in IVL; in particular , the expression of VEGFR-3 is dramatically different between IVL and LM .This indicates IVL and LM have different molecular alterations , which may play important roles in the pathogenesis and development of IVL .
