Antimicrobial Susceptibility of Multi-drug Resistant Acinetobacter Baumannii and Pseudomonas Aeruginosa Isolates from 27 Hospitals in China
10.3969/j.issn.1674-9081.2014.03.002
- VernacularTitle:全国27所医院多重耐药鲍曼不动杆菌及铜绿假单胞菌对12种抗菌药物的敏感性
- Author:
Xin FAN
1
;
Meng XIAO
;
Qi-Wen YANG
;
Hong-Tao DOU
;
Li-Na GUO
;
He WANG
;
Ying YUAN
;
Peng WANG
;
Ying ZHAO
;
Qi ZHANG
;
Yong-Hong XIAO
;
Ying-Chun XU
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院检验科
- Keywords:
multi-drug resistance;
Acinetobacter baumannii;
Pseudomonas aeruginosa;
antimicrobial susceptibility;
nosoco-mial infection
- From:
Medical Journal of Peking Union Medical College Hospital
2014;(3):253-258
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antimicrobial susceptibilities of nosocomial multi-drug resistant Acinetobacter baumannii ( MDR-AB) and multi-drug resistant Pseudomonas aeruginosa ( MDR-PA) isolates. Methods MDR-AB and MDR-PA isolates were collected between August 2011 and July 2012 from 27 hospitals in China.All isolates were collected from high quality samples with definite infection diagnoses , whilst isolates from sputum and screen samples were strictly excluded .Minimum inhibitory concentrations ( MICs) of 12 com-monly used antimicrobial agents were tested by broth microdilution method in a microbiology laboratory .CLSI clinical breakpoints ( CBPs) of pre-and post-revision were applied and compared in determination of MDR .Re-sults A total of 664 MDR-AB and 268 MDR-PA isolates were collected .Pan-drug resistant ( PDR) was detec-ted in four Pseudomonas aeruginosa but not in Acinetobacter baumannii.The majority of isolates were collected from ICUs and surgical wards .Colistin and tigecycline were the most active agents against MDR-AB (96.8%and 72.6% susceptible , respectively ) , while no other drug exhibited activity of >55%susceptible .Only 72.4%of MDR-PA isolates remained susceptible to colistin , but amikacin was more active to MDR-PA ( 64.2%) than MDR-AB (16.7%).By applying revised CBPs , the susceptibility of MDR-AB isolates to imipenem and mero-penem decreased by 1.3% and 0.6%, respectively , whereas the susceptibility of MDR-PA to these two drugs decreased by 5.5%and 8.6%, respectively .The carbapenems susceptible rate of isolates collected from ICUs was lower than surgical and other wards .Isolates collected from different geographic regions showed varied resist -ant profiles .Conclusions Colistin and tigecycline are the most active drugs against MDR-AB, while colistin and amikacin have comparably good performance to MDR-PA.
