Exploration and practice of novel models of cellular therapy and hematopoietic stem cell transplantation
10.3760/cma.j.cn121090-20230928-00150
- VernacularTitle:细胞治疗与造血干细胞移植新模式的探索与实践
- Author:
Xi ZHANG
1
;
Ruihao HUANG
Author Information
1. 陆军军医大学新桥医院血液病医学中心，创伤、烧伤与复合伤国家重点实验室，全军血液病中心，重庆市医学重点学科，重庆 400037
- Keywords:
Hematological malignancies;
Cell therapy;
Hematopoietic stem cell transplantation
- From:
Chinese Journal of Hematology
2024;45(2):105-108
- CountryChina
- Language:Chinese
-
Abstract:
Hematopoietic stem cell transplantation provides an effective cure for various hematological diseases, especially malignant hematological diseases, its treatment system has been continuously optimized, the source of donors has been expanding, the indications have been expanding, and the therapeutic effect has also made breakthroughs to a certain extent. At present, the status of hematopoietic stem cell transplantation technology in most hematological diseases is still unshakable, but the recurrence of the primary disease and complications related to hematopoietic stem cell transplantation are still two major clinical challenges that affect the long-term survival and quality of life of patients. Cell therapy represented by chimeric antigen receptor T (CAR-T) has made breakthrough progress in the treatment of refractory/recurrent B-cell malignancies. Compared with traditional drugs, cell therapy has unique in vivo metabolic characteristics, relying on immune specific recognition and the repair ability of stem cells. It is currently emerging in the treatment of blood tumors and the management of transplant complications. Multiple clinical studies have preliminarily demonstrated a new diagnostic and therapeutic model combining cell therapy with hematopoietic stem cell transplantation.
