The mechanism of bariatric surgery in the treatment of non-alcoholic fatty liver disease
10.3760/cma.j.cn115610-20240614-00296
- VernacularTitle:减重手术治疗非酒精性脂肪性肝病的作用机制
- Author:
Yiyang MIN
1
;
Peng ZHANG
;
Peirong TIAN
;
Mengyi LI
;
Jingyu ZHANG
;
Guanda LU
;
Zhongtao ZHANG
Author Information
1. 首都医科大学附属北京友谊医院普通外科中心 国家消化系统疾病临床医学研究中心 消化健康全国重点实验室，北京 100050
- Keywords:
Obesity;
Bariatric surgery;
Non-alcoholic fatty liver disease;
Insulin resis-tance;
Bile acid;
Intestinal flora
- From:
Chinese Journal of Digestive Surgery
2024;23(9):1231-1236
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease (NAFLD), as a metabolic disease, has shown a constant upward trend in prevalence among the people in recent years. In addition to changing lifestyles and conventional drug treatment, bariatric surgery, represented by Roux-en-Y gastric bypass surgery and sleeve gastrectomy, has gradually become one of the treatment options for NAFLD. However, the mechanism of bariatric surgery in treating NAFLD remains to be studied. The "multiple-hit theory", which has gradually been recognized in recent years, believes that NAFLD is formed by the combined effect of multiple mechanisms such as insulin resistance, bile acid metabolism pathway, and intestinal flora. Based on relevant literatures and clinical practices, the authors explore the relevant mechanisms of bariatric surgery for direct or indirect treatment of NAFLD.
