Establishment of Alzheimerˊs disease risk assessment model for elderly population
10.3760/cma.j.issn.1674-2907.2019.24.010
- VernacularTitle:老年人群阿尔茨海默病风险评估模型的构建
- Author:
Shasha PAN
1
;
Yan ZHAO
;
Jing SUN
Author Information
1. 北京大学护理学院 100191
- Keywords:
Alzheimer's disease;
Aged;
Risk assessment;
Model construction
- From:
Chinese Journal of Modern Nursing
2019;25(24):3076-3080
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo construct a comprehensive and simple risk assessment model for Alzheimer's disease (AD), which is suitable for the promotion of the elderly population, to predict the future risk of AD among the elderly and to intervene in the early stage. MethodsIn June 2018, risk factors were screened by literature review and brainstorming, and then combined with Meta-analysis reappraisal and structured expert consultation to screen risk factors and OR values into the model. Individual relative risk and absolute risk in the next five years were calculated according to the Harvard Cancer Index formula. ResultsThe model finally included 24 indicators: female, no spouse, education level, personality, family history of dementia, herpes virus infection, middle-aged hypertension, diabetes, stroke, brain injury, hearing impairment, periodontitis, depression, smoking, drinking alcohol, coffee/tea, deep-sea fish, vegetables and fruits, exercise, sleep, social life, waist circumference, serum homocysteine and serum thyroxine. ConclusionsThe model of individual AD risk established by modified Harvard Cancer Risk Index can predict the relative and absolute risk of Alzheimer's disease in the future, which provides the basis and guidance for screening and intervention of high-risk population.
