Clinical analysis of amphotericin B cholesteryl sulfate complex for injection in the treatment of invasive fungal disease for patients with hematological malignancies in 30 cases
10.3760/cma.j.issn.0253-2727.2022.10.008
- VernacularTitle:注射用两性霉素B胆固醇硫酸酯复合物治疗血液系统恶性肿瘤合并侵袭性真菌病30例临床分析
- Author:
Jun WANG
1
;
Song JIN
;
Xiaojin WU
;
Miao MIAO
;
Xiaowen TANG
;
Xuefeng HE
;
Huiying QIU
;
Yue HAN
;
Ying WANG
;
Weiyang LI
;
Caixia LI
;
Shengli XUE
;
Xiao MA
;
Depei WU
Author Information
1. 国家血液系统疾病临床医学研究中心，江苏省血液研究所，苏州大学附属第一医院血液科，苏州大学造血干细胞移植研究所，苏州 215006
- Keywords:
Invasive fungal disease;
Amphotericin B cholesteryl sulfate complex;
Empirical antifungal therapy;
Diagnostic-driven antifungal therapy
- From:
Chinese Journal of Hematology
2022;43(10):848-852
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the safety and effectiveness of amphotericin B cholesteryl sulfate complex for injection in the context of empirical and diagnostic antifungal therapy for patients with hematological malignancies in addition to invasive fungal illness.Methods:This single-arm clinical study enrolled 30 patients who received empirical and diagnostic-driven antifungal therapy for hematological malignancies combined with invasive fungal disease. The primary endpoint was safety. Response rate, fever duration, and treatment completion rate were all considered secondary objectives.Results:30 participants were eventually enrolled in the study, and the treatment completion rate was 80.0% . Most adverse events were in grades 1-2. Infusion response was the most frequent adverse event (24/30, 80% ) . The overall response rate was 80.0% (24/30) . In 24 patients (80.0% ) , the fever persisted for 1 day.Conclusions:Treatment of invasive fungal illness in conjunction with hematological malignancies showed good efficacy and safety with amphotericin B cholesteryl sulfate complex for injection.
