Utility and prognostic value of PET/CT, bone marrow biopsy and aspirate for detection of bone marrow involvement in diffuse large B-cell lymphoma
10.3760/cma.j.issn.0253-2727.2022.08.008
- VernacularTitle:PET/CT、骨髓活检及骨髓涂片评估弥漫大B细胞淋巴瘤骨髓侵犯的应用及预后价值
- Author:
Xianyong JIANG
1
;
Dongmei ZOU
;
Yingqiang ZHANG
;
Zi WANG
;
Wei ZHANG
;
Daobin ZHOU
;
Yan ZHANG
Author Information
1. 中国医学科学院、北京协和医学院北京协和医院血液内科，北京 100730
- Keywords:
Lymphoma, large B-cell, diffuse;
Bone marrow biopsy;
Bone marrow aspirate;
Positron emission tomography combined with computed tomography
- From:
Chinese Journal of Hematology
2022;43(8):663-667
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to determine the value of bone marrow biopsy (BMB) , bone marrow aspiration (BMA) , and positron emission tomography combined with computed tomography (PET/CT) in bone marrow (BM) involvement and prognosis evaluation in diffuse large B-cell lymphoma (DLBCL) .Methods:The clinical data of patients with DLBCL who underwent PET/CT, BMB, and BMA of the iliac crest were retrospectively analyzed in Peking Union Medical College Hospital from January 2015 to November 2017. The BM involvement on PET/CT was defined as the ratio of maximal standardized uptake values of iliac crest BM to liver parenchyma intensity ≥1.Results:A total of 76 patients without liver involvement were enrolled, there were 32 males, and the median age was 53 (17-79) . Moreover, 16 patients (21.1%) had BM involvement on PET/CT, 12 (15.8%) had positive BMB, and 13 (17.1%) had positive BMA. Excellent correlation between BMA and BMB ( κ=0.943) was found, including good correlation between PET/CT and BMB/BMA ( κ=0.763 and 0.776, respectively) . After a median follow-up of 52 (0-82) months, BM involvement by BMB ( P=0.037) and BMA ( P=0.007) were poor prognostic factors for overall survival, positive PET/CT had no significant effect on prognosis ( P>0.05) . Conclusion:PET/CT, BMB, and BMA are effective methods to detect BM involvement with great concordance. However, iliac crest BMB and BMA showed superior performance in prognosis evaluation.
