Research progress of mechanosensitive ion channel Piezo1 in immune cells and pancreatitis
10.3760/cma.j.cn115610-20240411-00201
- VernacularTitle:机械敏感性离子通道Piezo1在免疫细胞和胰腺炎中的研究进展
- Author:
Rujuan LIU
1
;
Zheng WANG
;
Li WEN
;
Feng CAO
Author Information
1. 中国医学科学院北京协和医院临床医学研究所生物标志物研究平台，北京 100073
- Keywords:
Pancreatitis;
Mechanical signals;
Immune cells;
Ion channels;
Piezo1
- From:
Chinese Journal of Digestive Surgery
2024;23(5):754-760
- CountryChina
- Language:Chinese
-
Abstract:
As a mechanosensitive ion channel, Piezo1 is expressed in various immune cells and plays an important role in mediating immune response by calcium influx in response to mech-anical signals. Pancreatic parenchymal cells are highly sensitive to mechanical stress. Piezo1 can respond to mechanical stimuli during the initiation and development of pancreatitis. The authors summarize the latest research advancements on the role and molecular mechanisms of Piezo1 in various immune cells and pancreatitis in recent years and discuss the potential role of immune cell Piezo1 in acute and chronic pancreatitis, with an attempt to provide new insights for early inter-vention of pancreatitis.
