Clinical application value and research prospects of tertiary lymphoid structures in pancreatic cancer
10.3760/cma.j.cn115610-20240423-00221
- VernacularTitle:三级淋巴结构在胰腺癌的临床应用价值和研究展望
- Author:
Yinmo YANG
1
;
Enkui ZHANG
;
Yongsu MA
;
Yu ZHU
Author Information
1. 北京大学第一医院肝胆胰外科，北京 100034
- Keywords:
Pancreatic neoplasms;
Tertiary lymphoid structures;
Immunotherapy;
Tumor microenvironment;
Application and prospects
- From:
Chinese Journal of Digestive Surgery
2024;23(5):647-652
- CountryChina
- Language:Chinese
-
Abstract:
The special suppressive tumor immune microenvironment is a significant factor in the high postoperative recurrence rate and insensitivity to immunotherapy in pancreatic cancer. Tertiary lymphoid structures (TLSs) are pathologic ectopic lymphoid tissues composed of various immune cells, playing a crucial role in regulating adaptive anti-tumor immune responses. The presence of TLSs in pancreatic cancer tissues signifies better prognosis and immune therapy response. Examining the quantity, location, maturity, and cellular components of TLSs in pancreatic cancer specimens helps predict prognosis and screen potential beneficiaries of immunotherapy. Exploring key factors inducing TLSs formation and elucidating the anti-tumor immune mechanisms of TLSs may provide a new theoretical basis for enhancing the efficacy of pancreatic cancer immunotherapy. The authors summarize the clinical status and hot topics of TLSs in pancreatic cancer applications, and look forward to the research directions of TLSs in the field of pancreatic cancer.
