Splenectomy for the treatment of common variable immunodeficiency complicated with cytopenia: report of one case and literature review
10.3760/cma.j.issn.0253-2727.2021.10.009
- VernacularTitle:脾切除治疗普通变异型免疫缺陷病合并血细胞减少一例报告并文献复习
- Author:
Cuiyun QU
1
;
Wei LIU
;
Rongfeng FU
;
Yunfei CHEN
;
Xiaofan LIU
;
Lei ZHANG
;
Renchi YANG
;
Feng XUE
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所），实验血液学国家重点实验室，国家血液系统疾病临床医学研究中心，天津 300020
- Keywords:
Common variable immunodeficiency;
Autoimmune cytopenia;
Splenectomy
- From:
Chinese Journal of Hematology
2021;42(10):846-850
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To improve the understanding of splenectomy for treating common variable immunodeficiency complicated with cytopenia.Methods:A case of common variable immunodeficiency complicated with cytopenia was reported, and the literature was reviewed.Results:The patient, female, 16 years old, was hospitalized for eight years due to thrombocytopenia; she manifested recurrent thrombocytopenia with leukopenia since adolescence. The patient was diagnosed with common variable immunodeficiency with repeated mild infections, splenomegaly, and significantly reduced plasma immunoglobulin levels. Additionally, splenectomy was performed with adequate immunoglobulin replacement therapy, and the pathology confirmed hypersplenism; her blood cell level returned to normal after surgery.Conclusions:Common variable immunodeficiency has various clinical manifestations and can be complicated with cytopenia. Under the premise of adequate immunoglobulin replacement therapy, splenectomy is a safe and effective treatment for common variable immunodeficiency in patients with recurrent cytopenia.
