Relationship between serum a proliferation-inducing ligand and C-X-C motif-chemokine ligand 14 expression and disease outcome in children with severe mycoplasma pneumoniae pneumonia
10.3760/cma.j.issn.1673-4912.2024.11.009
- VernacularTitle:重症肺炎支原体肺炎患儿血清增殖诱导配体、C-X-C基序趋化因子配体表达与疾病转归的关系
- Author:
Ying LIU
1
;
Rongping ZHU
;
Lin ZHANG
Author Information
1. 常州市妇幼保健院新生儿科213000
- Keywords:
Severe pneumonia;
Mycoplasma pneumonia;
A proliferation inducing ligand;
C-X-C motif-chemokine ligand 14;
Disease regression;
Children
- From:
Chinese Pediatric Emergency Medicine
2024;31(11):846-850
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the expression of serum a proliferation inducing ligand (APRIL), C-X-C motif-chemokine ligand 14(CXCL14) and disease regression in children with severe Mycoplasma pneumoniae pneumonia (SMPP).Methods:A total of 112 children with SMPP admitted to Changzhou Maternal and Child Health Hospital from January 2021 to December 2022 were selected as study subjects. After 28 d of treatment, the children were divided into the good prognosis group ( n=87) and the poor prognosis group ( n=25) according to their disease regression, and 100 children with Mycoplasma pneumoniae pneumoniae (MPP) admitted to our hospital during the same period were selected as the control group. Serum APRIL and CXCL14 expression were measured by enzyme-linked immunosorbent assay in all children. The predictive value of serum APRIL and CXCL14 for disease regression in children with SMPP was assessed by receiver operating characteristic (ROC) curve, and the factors influencing disease regression in children with SMPP were analyzed by multifactorial Logistic stepwise regression. Results:Serum APRIL and CXCL14 levels in the study group were higher than those in the control group（all P<0.05）. Serum APRIL and CXCL14 levels of children with SMPP in the poor prognosis were higher than those in the good prognosis group（all P<0.05）. The area under the curve (AUC)（95% CI）of serum APRIL and CXCL14 for predicting the prognosis of SMPP children were 0.783（0.721-0.835）and 0.835（0.789-0.882），respectively，and the cut-off values were 34.47 ng/mL and 289.32 pg/mL，respectively. The specificity was 53.61%，65.43%，and the sensitivity was 93.20%，93.20%，respectively. The AUC（95% CI）of the combined detection of both was 0.913（0.872-0.954），with a specificity of 85.59% and a sensitivity of 86.35%. The proportions of children in the poor prognosis group with fever days> 7 d and admission National Institute of Health Stroke Scale(NIHSS) score> 30 points were higher than those in the good prognosis group（ P<0.05）. Multifactorial Logistic stepwise regression analysis showed that the fever days> 7 d（ OR=2.273，95% CI 1.403-3.681），admission NIHSS score> 30 points（ OR=2.088，95% CI 1.327-3.283），APRIL≥34.47 ng/mL（ OR=3.093，95% CI 1.711-5.590），and CXCL14≥289.32 pg/mL（ OR=5.013，95% CI 2.079-12.086）were risk factors for death in children with SMPP（ P<0.05）. Conclusion:Serum APRIL and CXCL14 are highly expressed in children with SMPP and are associated with disease regression, which may serve as potential markers for predicting the prognosis of children with SMPP.
