The hematological diversity of human parvovirus B19 infection after allo-hematopoietic stem cell transplantation in pediatric patients
10.3760/cma.j.issn.0253-2727.2021.08.007
- VernacularTitle:儿童异基因造血干细胞移植后人类细小病毒B19感染的血液学表现
- Author:
Luyang ZHANG
1
;
Fang LIU
;
Xia CHEN
;
Xiaoyan ZHANG
;
Yuanyuan REN
;
Ranran ZHANG
;
Wenyu YANG
;
Ye GUO
Author Information
1. 中国医学科学院北京协和医学院血液病医院（中国医学科学院血液学研究所）儿童血液病诊疗中心，实验血液学国家重点实验室，国家血液系统疾病临床医学研究中心，天津 300020
- Keywords:
Human parvovirus B19;
Hematopoietic stem cell transplantation;
Children
- From:
Chinese Journal of Hematology
2021;42(8):654-659
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To retrospectively analyze hemogram and bone marrow characteristics of pediatric patients infected with parvovirus B19 (HPV-B19) after hematopoietic reconstitution following allo-hematopoietic stem cell transplantation.Methods:The clinical course of nine patients with HPV-B19 infection, including hemogram and bone marrow smear analysis during infection, were retrospectively analyzed.Results:Despite the hematological heterogeneity, all patients exhibited reduced hemoglobin levels accompanied by reticulocytes. The proportion and absolute count of reticulocytes decreased by 90.4% (24.7% -98.7% ) and 90.7% (18.6% -99.0% ) , respectively, in one week. Additionally, five patients manifested a decline in neutrophil granulocyte count in peripheral blood whereas granulocytic hypoplasia was not observed in bone marrow. Furthermore, six patients exhibited megakaryocytic hypoplasia in bone marrow, including five patients with decreased platelet counts in peripheral blood. Importantly, only some patients exhibited erythroid hypoplasia although all patients exhibited a decline in hemoglobin in peripheral blood. Erythroid hypoplasia in bone marrow was present in five patients.Conclusion:There was heterogeneity in hemogram and bone marrow smear characteristics among pediatric patients infected with HPV-B19 following allo-hematopoietic stem cell transplantation. Anemia accompanied by decreased reticulocyte count should prompt screening for HPV-B19 in these patients
