Death is coming:hemophagocytic lymphohistiocytosis complicated by coagulation disorders
10.3760/cma.j.issn.1673-4912.2024.11.005
- VernacularTitle:“Death is coming”：噬血细胞综合征合并出凝血功能障碍
- Author:
Wenjia TONG
1
;
Danqun JIN
Author Information
1. 安徽省儿童医院重症医学科，合肥 230051
- Keywords:
Hemophagocytic lymphohistiocytosis;
Coagulation disorders;
Disseminated intravascular coagulation;
Hemophagocytic syndrome
- From:
Chinese Pediatric Emergency Medicine
2024;31(11):825-830
- CountryChina
- Language:Chinese
-
Abstract:
Hemophagocytic lymphohistiocytosis（HLH）is a complex，rapidly progressing，and highly fatal disease that can lead to during multiple organ dysfunctions.Coagulation disorders frequently occur during the course of HLH and are a significant cause of early mortality.Early diagnosis of coagulation disorders or disseminated intravascular coagulation（DIC）in such patients is particularly challenging，as HLH itself interferes with the diagnostic markers associated with coagulation disorders or DIC.This article summarized the current state of research on HLH complicated by coagulation disorders，including its pathogenesis and the common and novel coagulation markers used in the collaborative assessment of HLH complicated by coagulation disorders or DIC.The goal was to provide more opportunities for subsequent treatment of the underlying disease.
