Clinical early warning and therapeutic interventions of hemophagocytic syndrome associated with Epstein-Barr virus infection
10.3760/cma.j.issn.1673-4912.2024.11.004
- VernacularTitle:EB病毒感染相关噬血细胞综合征的临床预警及治疗
- Author:
Jinpeng GAN
1
;
Longlong XIE
;
Xiulan LU
Author Information
1. 南华大学儿科学院,长沙410007
- Keywords:
Hemophagocytic syndrome;
Epstein-Barr virus;
Clinical early warning
- From:
Chinese Pediatric Emergency Medicine
2024;31(11):818-824
- CountryChina
- Language:Chinese
-
Abstract:
Hemophagocytic syndrome，synonymous with hemophagocytic lymphohistiocytosis（HLH），represent a spectrum of hyperinflammatory response syndromes that have been the subject of intense scrutiny in terms of their etiopathogenesis and early warning strategies.Ebstein-Barr virus（EBV）-associated HLH is the most prevalent form of infection-associated secondary HLH.It is characterized by a sudden onset，rapid progression，and high mortality rate.The primary clinical features include persistent fever，often accompanied by manifestations of multi-system involvement，such as cytopenias，hepatosplenomegaly，lymphadenopathy，abnormal liver function，respiratory symptoms，neurological symptoms，and rashes.Therefore，early recognition and warning are crucial for improving the prognosis of patients with EBV-HLH.This article aimed to focus on the relationship between EBV and HLH，the diagnosis of EBV-HLH，associated warning factors，and treatment strategies.
