Chronic lymphocytic leukemia with t (14;18) (q32;q21) : report of eight cases and a literature review
10.3760/cma.j.issn.0253-2727.2021.07.008
- VernacularTitle:伴t(14;18)(q32;q21)的慢性淋巴细胞白血病八例报告并文献复习
- Author:
Jianyong LI
1
;
Jing ZHANG
;
Hairong QIU
;
Hui YANG
;
Rui GUO
;
Yi MIAO
;
Huayuan ZHU
;
Li WANG
;
Lei FAN
;
Wei XU
Author Information
1. 南京医科大学第一附属医院，江苏省人民医院血液科 210029
- Keywords:
Leukemia, lymphocytic, chronic;
t (14;
18) (q32;
q21);
Clinical features;
Prognosis
- From:
Chinese Journal of Hematology
2021;42(7):577-582
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The study aimed to analyze the clinical features and prognosis of chronic lymphocytic leukemia (CLL) with t (14;18) (q32;q21) and conduct a literature review.Methods:The clinical data of 8 patients with CLL carrying t (14;18) (q32;q21) seen in Jiangsu Province Hospital from November 2009 to November 2019 were collected and analyzed.Results:Among the 8 cases, 7 were male and 1 was female. The median age at diagnosis was 70 years old. The immunophenotype score was 5 in 3 patients. 4 patients were scored 4 and the remaining one scored 3. The bone marrow histopathology showed the typical manifestation of CLL. Karyotype analysis showed that all the cases carried t (14;18) (q32;q21) in the stemline. The t (14;18) (q32;q21) showed as the sole abnormality in 3 cases, with +12 in 4, and with 13q- in 1 case. 13q- was found in another 3 patients by FISH. Immunoglobulin heavy chain gene (IGHV) mutation status was detected in 6 cases and all of them were mutated. None of them used IGHV3-21. Only 1 case harbored TP53 mutation and no TP53, SF3B1, NOTCH1, or MYD88 mutations were found in the remaining cases who underwent the relevant tests. At a median follow-up of 30.9 months, 1 case died. The remaining 7 cases survived and 3 of them have not reached the treatment indication. 4 patients who received chemotherapy or immunotherapy were stable.Conclusions:The t (14;18) (q32;q21) is rare in CLL and often accompanied by +12 and mutated IGHV. CLL with t (14; 18) (q32; q21) tends to have a good prognosis.
