Clinical characteristics and prognostic risk factors analysis of carbapenem-resistant organism in the department of hematology
10.3760/cma.j.issn.0253-2727.2021.07.006
- VernacularTitle:血液科碳青霉烯耐药革兰阴性菌感染的临床特征及预后危险因素分析
- Author:
Shaozhen CHEN
1
;
Jingjing XU
;
Tingting XIAO
;
Yingxi WENG
;
Dabing CHEN
;
Yu ZHANG
;
Jinhua REN
;
Xiaofeng LUO
;
Zhihong ZHENG
;
Xiaoyun ZHENG
;
Zhizhe CHEN
;
Jianda HU
;
Ting YANG
Author Information
1. 福建医科大学附属协和医院血液科，福建省血液病学重点实验室，福建省血液病研究所，福州 350001
- Keywords:
Carbapenem-Resistant Organism;
Carbapenem-Resistant Enterobacteriaceae;
Risk factor
- From:
Chinese Journal of Hematology
2021;42(7):563-569
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the distribution and drug resistance of Carbapenem-Resistant Organism (CRO) and to analysis the risk factors of CRO 30-day mortality.Methods:A total of 181 patients with CRO infection diagnosed in Department of Hematology, Fujian Medical University Union Hospital from January 2018 to June 2020 were retrospectively investigated. The clinical and laboratory data of the patients were collected, the prognosis of patients diagnosed with CRO infection in day 30 was followed up, and the risk factors of prognosis were analyzed. The clinical significance of Carbapenem-Resistant Enterobacteriaceae (CRE) active screening was further evaluated in the CRE subgroup.Results:Among the total of 181 CRO isolates, 47.2% were CRE, 37.0% were Pseudomonas aeruginosa, and 32.6% were Klebsiella pneumoniae, which were highly resistant to carbapenem and had high MIC value, 76.8% (139/181) of CRO were MIC of imipenem resistance≥16 μg/ml. The main sources of isolates were blood and sputum. The 30-day all-cause mortality rates of patients with CRO or CRE infection were (41.4±3.7) % and (44.7±5.4) %, respectively. The COX multivariate regression analysis showed that the level of procalcitonin >0.2 ng/ml and the MIC value of imipenem resistance ≥ 16 μg/ml were independent risk factors for 30-day mortality of CRO infected patients. The CRE subgroup analysis showed that MIC value of imipenem resistance ≥16 μg/ml were independent risk factors for 30-day mortality of CRE infected patients. The 30-day cumulative survival rate of patients with CRE active screening was higher than the patients without CRE active screening [ (68.0±9.3) % vs (50.0±6.5) %, P=0.21]. Conclusion:The high MIC value of imipenem resistance isolates seriously affects the prognosis of patients with CRO infection in the hematology department, and the mortality rate was high. CRE active screening is expected for early prevention, early diagnosis, and early treatment for high-risk patients.
