Clinical characteristics of adenovirus pneumonia in children with atopic constitution
10.3760/cma.j.issn.1673-4912.2024.10.008
- VernacularTitle:特应性体质患儿腺病毒肺炎临床特征研究
- Author:
Jialin LYU
1
;
Wenjian WANG
Author Information
1. 中国医科大学深圳市儿童医院呼吸内科 518038
- Keywords:
Atopic constitution;
Adenovirus pneumonia;
Clinical features;
Children
- From:
Chinese Pediatric Emergency Medicine
2024;31(10):761-766
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the clinical characteristics of adenovirus pneumonia in children with atopic constitution.Methods:Children diagnosed with adenovirus pneumonia with atopic constitution at Shenzhen Children's Hospital from January 1, 2018 to December 31, 2022 were selected as the study subjects (atopic constitution group), and their clinical data, such as basic information, clinical manifestations (including symptoms, signs, etc.), laboratory indexes, co-infected pathogens, main treatment measures, complications, and incidence of severe pneumonia were retrospectively analyzed, and compared with children hospitalized with adenovirus pneumonia in non-atopic constitution during the same period (non-atopic constitution group).Results:A total of 190 children with atopic somatic adenovirus pneumonia were included, including 129 (67.90%) males and 61 (32.10%) females,whose median age was 31(15,48) months, and hospitalization time was 6.00 (4.00, 8.25) days. The differences in shortness of breath(37.9% vs. 28.0%), wheezing(58.9% vs. 27.2%), rales(23.7% vs. 9.5%), pleural effusion(12.1% vs. 20.5%), anemia(22.6% vs. 31.1%), co-infections(72.1% vs. 62.9%), ultrasensitive C-reactive protein[11.99(3.55,27.67) mg/L vs. 16.50(6.44,35.46) mg/L], albumin[39.30(36.95,42.05) g/L vs. 38.10(35.00,40.20)g/L] and percentage of oxygen therapy(36.8% vs. 28.6%) were statistically significant between the children in atopic group and non-atopic group (all P<0.05).Multifactorial Logistic regression analysis revealed that fever duration >7.5 days, manifestation of shortness of breath and fine wet rales, platelet count >390×10 9/L and aspartate aminotransferase>33.50 IU/L were independent risk factors for the development of severe pneumonia in children with atopic somatic adenovirus pneumonia( P<0.05). Conclusion:Children with atopic adenovirus pneumonia have a higher incidence of shortness of breath, wheezing, and rales during hospitalization than the non-atopic group, are more susceptible to co-infections, and have a higher rate of needing oxygen therapy; prolonged duration of fever, shortness of breath, and fine wet rales, as well as high values of platelets and aspartate aminotransferase, can be used as a predictive indicator of severe adenovirus pneumonia in children with atopic constitution.
