Autologous stem cell transplantation improve the survival of newly diagnosed multiple myeloma patients
10.3760/cma.j.issn.0253-2727.2021.05.007
- VernacularTitle:自体造血干细胞移植治疗初治多发性骨髓瘤的临床分析
- Author:
Chuanying GENG
1
;
Guangzhong YANG
;
Guorong WANG
;
Huijuan WANG
;
Huixing ZHOU
;
Zhiyao ZHANG
;
Yuan JIAN
;
Wenming CHEN
Author Information
1. 首都医科大学附属北京朝阳医院血液科，北京 100020
- Keywords:
Multiple myeloma;
Autologous stem cell transplantation;
Survival;
Prognostic factors
- From:
Chinese Journal of Hematology
2021;42(5):390-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of autologous stem cell transplantation (auto-HSCT) on treatment remission and survival of newly diagnosed multiple myeloma (MM) patients.Methods:A total of 243 new diagnosed MM patients (age ≤65 years) who had received auto-HSCT were selected, and 176 MM patients (age ≤65 years) who had not received auto-HSCT were selected as the control group to evaluate the effect of auto-HSCT on the remission and survival. To balance the distribution of prognostic factors between auto-HSCT and non-auto-HSCT patients, the propensity score matching technique was used to reduce the bias between groups in a 1∶1 scale, 64 in each group, and correlation analysis was performed.Results:A total of 128 patients (64 cases in each group) were screened by propensity score matching analysis. 64 patients received auto-HSCT after induction therapy. After auto-HSCT, 24 patients (37.5%) obtained sCR, 16 patients (25.0%) obtained CR, 15 patients (23.4%) obtained VGPR, and 9 patients (14.1%) obtained PR. The efficacy of patients with auto-HSCT was significantly better than that of non-auto-HSCT patients ( P=0.032) . Progression-free survival (PFS) and overall survival (OS) were significantly longer in auto-HSCT patients compared with non-auto-HSCT patients[PFS: 42.2 (95% CI 29.9-54.5) months vs 22.4 (95% CI 17.1-27.7) months, P=0.007; OS: 87.6 (95% CI 57.3-117.9) months vs 53.9 (95% CI 36.1-71.7) months, P=0.011]. Multivariate analysis confirmed that auto-HSCT had a favorable effect on OS ( HR=0.448, 95% CI 0.260-0.771, P=0.004) and PFS ( HR=0.446, 95% CI 0.280-0.778, P=0.003) . Conclusion:These results demonstrated that auto-HSCT was a favorable prognostic factor for newly diagnosed MM patients.
