Influence of prognostic nutritional index and controlling nutritional status on the prognosis of patients with multiple myeloma
10.3760/cma.j.issn.0253-2727.2021.04.011
- VernacularTitle:预后营养指数、控制营养状况对多发性骨髓瘤患者预后的影响
- Author:
Fei LIANG
1
;
Xueyan DONG
;
Guofeng TANG
;
Kunming QI
;
Wei CHEN
;
Wei SANG
;
Haiying SUN
;
Jiang CAO
;
Hai CHENG
;
Depeng LI
;
Zhenyu LI
;
Kailin XU
Author Information
1. 徐州医科大学附属医院血液科，徐州 221002
- Keywords:
Multiple myeloma;
Prognostic nutritional index;
Nutritional status;
Prognosis
- From:
Chinese Journal of Hematology
2021;42(4):332-337
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the influence of prognostic nutritional index (PNI) and controlling nutritional status (CONUT) on the prognosis of patients with multiple myeloma.Methods:Data of 157 patients with multiple myeloma (MM) at the affiliated hospital of Xuzhou medical university from January 2014 to December 2018 were retrospectively evaluated. The operating characteristic (ROC) curve analysis was adopted as the optimal cut-off point. PNI and CONUT were grouped based on the cut-off points of 44.45 and 3.5, respectively, and the differences between age, gender, serum calcium, β 2-microglobulin, serum creatinine, lactate dehydrogenase, and hemoglobin were analyzed. The prognostic factors were analyzed via univariate and Cox multivariate regression analyses. Results:The level of PNI and CONUT is the influencing factor of OS time. The univariate analysis revealed that age, LDH, plasma cell ratio, β 2-microglobulin, ISS stage, PNI, and CONUT were the risk factors for the prognosis of patients with MM. The multivariate analysis revealed that age ( HR=1.636, 95% CI 1.014-2.640) , plasma cell ratio ( HR=1.953, 95% CI 1.232-3.096) , and PNI ( HR=0.513, 95% CI 0.287-0.917) were the independent prognostic risk factors of patients with MM. Conclusion:Low PNI in patients with MM indicates a poor prognosis, which is an independent prognosis risk factor.
