Research progress on intestinal microecological in chronic kidney disease

VernacularTitle:肠道微生态在慢性肾脏病中的研究进展
Author: Lin ZHU ¹ ; Jie NIU ; Lan XIAO ; Lingyun YIN ; Yangyang YU ; Yuqing WANG ; Ping ZHOU
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1. 四川省妇幼保健院　成都医学院附属妇女儿童医院儿童肾脏风湿免疫科　四川省儿童肾病临床医学研究中心　610031
Keywords: Chronic kidney disease; Intestine-kidney axis; Intestinal microecology; Intestinal mucosal barrier; Intestinal microecological agents
From: Chinese Pediatric Emergency Medicine 2024;31(8):632-636
CountryChina
Language:Chinese
Abstract: Chronic kidney disease（CKD）has a significant impact on global public health and is one of the important factors leading to the rise of incidence rate and mortality of non communicable diseases.Intestinal microecology is involved in many pathophysiological activities，such as immunity and nutrient absorption.With proposal of the concept of intestine-kidney axis in 2002，researchers found that the decline of glomerular filtration rate led to accumulation of uremic toxins in intestine，destroyed the intestinal mucosal barrier，led to the translocation of toxins，activated the systemic oxidative stress response，further promoted the progress of CKD.This article reviewed the function of gut microbiota，intestine-gut kidney axis，and the application of microbial preparations in CKD.