Research progress on epigenetic in pulmonary arterial hypertension

VernacularTitle:肺动脉高压发病机制中表观遗传学的研究进展
Author: Jie ZHANG ¹ ; Youpeng JIN ; Peng YANG
Author Information

1. 山东第一医科大学附属省立医院小儿重症医学科，济南　250021
Keywords: Epigenetics; Pulmonary arterial hypertension; DNA methylation; Histone modifications; Non-coding RNAs
From: Chinese Pediatric Emergency Medicine 2024;31(8):628-631
CountryChina
Language:Chinese
Abstract: Pulmonary arterial hypertension（PAH）is a clinical syndrome characterized by increased pulmonary vascular resistance and elevated pulmonary arterial pressure，which subsequently leads to right heart failure and even death.PAH is caused by a variety of etiologic and pathogenic mechanisms，including congenital and acquired.Epigenetics is the study of the altered expression and function of genes that produce heritable phenotypes without changes in DNA sequence，and it bridges the relationship between environment and heredity.There is growing evidence that epigenetic modifications，including DNA methylation，histone modifications，and non-coding RNA，play important roles in the development of PAH.This review focused on the mechanisms and progress of epigenetic involvement in the development of PAH.