Predictive values of general movements qulity assessment and amplitude-integrated electroencephligram in motor development outcomes of neonates with severe hyperbilirubinemia
10.3760/cma.j.issn.1673-4912.2024.07.009
- VernacularTitle:振幅整合脑电图联合全身运动扭动阶段评估在新生儿重度胆红素血症发育结局的预测价值
- Author:
Fei YAN
1
;
Li XU
;
Hua MEI
;
Yan ZHANG
;
Kang SUN
;
Xiufeng NIU
Author Information
1. 内蒙古医科大学附属医院新生儿科，呼和浩特 010050
- Keywords:
Hyperbilirubinemia;
Neonates;
Amplitude-integrated Electroencephligram;
Kernicterus;
General movements assessment;
Motor development
- From:
Chinese Pediatric Emergency Medicine
2024;31(7):523-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the early predictive value of amplitude-integrated electroencephalogram(aEEG) combined with general movements（GMs）assessment for motor development outcomes in infants with severe hyperbilirubinemia at 12 months of age.Methods:The clinical data of 125 cases of neonates with severe hyperbilirubinaemia admitted to the NICU at Inner Mongolia Medical University Hospital from January 2020 to June 2022 were retrospectively analyzed.The aEEG were performed within 24 h of admission；GMs assessment were carried out at the duration of hospital stay，when the serum bilirubin values decreased below phototherapy intervention value and the infant was stable. The patients were regularly followed-up until one-year-old to evaluate the predictive values by Griffiths Developmental Scale.Results:A total of 125 infants with severe hyperbilirubinemia were enrolled，including 82（65.6%）males and 73（58.4%）females，with the mean gestational age of（38.1±1.5）weeks，the mean birth weight of（3 169±573）g，and the mean serum bilirubin of（378.5±51.9）μmol/L. Of the 125 infants diagnosed by Griffiths assessment at the age of 12 months，normal in 86 cases（68.8%），and abnormal in 39 cases（31.2%）. GMs writhing phase assessment had a sensitivity of 100%, negative predictive value of 100% and specificity of 19.77% in predicting motor developmental outcome in neonates with severe hyperbilirubinaemia. The aEEG had a sensitivity of 92.31% and a negative predictive value of 94.92% in predicting motor developmental outcome in neonates with severe hyperbilirubinaemia, with a higher specificity of 65.12%. The sensitivity and negative predictive value of aEEG+GMs assessment for predicting motor developmental outcome in neonates with severe hyperbilirubinaemia were 87.18% and 92.42%, respectively, with the highest specificity of 70.93%.Conclusion:GMs writhing stage assessment, aEEG assessment, and aEEG combined with GMs early assessment have good predictive value for motor developmental outcomes in neonates with severe hyperbilirubinaemia.The aEEG combined with GMs assessment has a high specificity, which can improve the predictive effect of motor developmental outcomes in neonates with hyperbilirubinaemia.
