Hypertrophic cardiomyopathy in children:a clinical analysis of 184 cases
10.3760/cma.j.issn.1673-4912.2024.07.005
- VernacularTitle:184例儿童肥厚型心肌病临床分析
- Author:
Zhen ZHEN
1
;
Xi CHEN
;
Jia NA
;
Yeqiong XU
;
Lu GAO
;
Yue YUAN
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院心脏内科 100045
- Keywords:
Hypertrophic cardiomyopathy;
Children;
Prognosis
- From:
Chinese Pediatric Emergency Medicine
2024;31(7):501-506
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical features and prognosis of hypertrophic cardiomyopathy（HCM）in children.Methods:The clinical data of 184 children diagnosed as HCM,who visited Beijing Children's Hospital of Capital Medical University from January 1，2006 to August 31，2022 were retrospectively analyzed.The children were divided into primary HCM group and secondary HCM group according to the etiology of HCM，and their clinical characteristics and prognosis were compared.Results:A total of 184 children[115（62.50%）males and 69(37.50%) females] with HCM were included.The median age at first diagnosis was 4.54（0.50，10.25）years.Among the participants，141（76.63%）cases had primary HCM，and 43（23.37%）cases had secondary HCM.Compared with the patients in primary HCM group，the patients in secondary HCM group had lower age of onset，with a higher proportion of the children under 1 year of age.Most cases had atypical symptoms，including a higher proportion of first-onset heart failure，higher proportion of enlarged cardiac shadow on chest radiograph，and lower left ventricular ejection fraction in the secondary HCM group（ P<0.05）.The proportion of older children，ratio of ventricular septal thickness to left ventricular posterior wall thickness，and the detection rate of left ventricular outflow tract obstruction in the primary HCM group was higher than those in patients with secondary HCM group（ P<0.05）.The survival curve for two groups showed that the secondary HCM group had significantly lower 1-year，2-year，3-year，5-year，and 10-year survival rates than those in the primary HCM group（ P<0.05）. Conclusion:The clinical manifestations of HCM in children are heterogenous due to different etiology，and it is necessary to actively clarify the etiology，improve risk assessment，and provide personalized management and treatment method.
