Expression of iron-regulating erythroid factors in different types of erythropoiesis disorders
10.3760/cma.j.issn.0253-2727.2021.01.010
- VernacularTitle:铁代谢红系调节因子在不同类型红系造血异常疾病中的表达
- Author:
Xu LIU
1
;
Jing HU
;
Xiangrong HU
;
Xiaoxia LI
;
Dongrui GUAN
;
Jingqian LIU
;
Yali ZHANG
;
Fengkui ZHANG
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所）、实验血液学国家重点实验室、国家血液系统疾病临床医学研究中心，天津 300020
- Keywords:
Iron-regulatory erythroid factor;
Erythroferrone;
Growth differentiation factor 15;
Growth differentiation factor 11;
Twisted gastrulation
- From:
Chinese Journal of Hematology
2021;42(1):52-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of iron-regulating erythroid factors in different types of erythropoiesis disorders.Methods:From January 2016 to November 2019, the plasma concentrations of iron-regulating erythroid factors were measured by ELISA methods in 47 patients with different types of erythropoiesis disorders. The adaptation orientation of iron-regulating erythroid factor expression with bone marrow erythropoiesis activities (represented by bone marrow-nucleated erythrocytes ratio) was analyzed.Results:The median plasma growth differentiation factor (GDF) 15 levels in patients with polycythemia vera (PV) , pure red cell aplasia (PRCA) , autoimmune hemolytic anemia (AIHA) , and myelodysplastic syndrome (MDS) were 266.01 ng/L (112.40, 452.37) , 110.63 ng/L (81.41, 220.42) , 52.11 ng/L (32.61, 171.66) , and 276.53 (132.16, 525.70) ng/L, respectively, which were significantly higher than those in normal patients with 37.45 (19.65, 57.72) ng/L (all P < 0.01) . The plasma TWSG1 expression levels were not significantly different in patients with PV, PRCA, AIHA, and MDS from those of normal patients (P>0.05) . The median plasma GDF11 level in PV was 74.75 (10.95, 121.32) ng/L, which was significantly higher than 36.90 (3.38, 98.34) ng/L in normal control subjects ( P<0.01) . However, no statistical differences were observed in the other three subjects ( P>0.05) . The median plasma erythroferrone (ERFE) levels in AIHA and PV were 121.76 ng/L (68.12, 343.11) and 129.63 (47.02, 170.03) ng/L, respectively, with the highest level in AIHA in all the studied types of erythropoiesis disorders. The bone marrow-nucleated erythrocytes ratio was significantly and positively correlated with ERFE ( r=0.458, P=0.001) but not with GDF15 ( r=-0.163, P=0.274) , GDF11 ( r=0.120, P=0.421) , and TWSG1 ( r=-0.166, P=0.269) . Conclusion:The expression profile of iron-regulating erythroid factors is not exactly the same in different types of erythropoiesis disorders. ERFE demonstrated the highest correlation with erythropoiesis activities.
