Analysis of the clinicopathologic features as well as diagnosis and treatment of 59 patients with Castleman disease
10.3760/cma.j.issn.0253-2727.2020.08.009
- VernacularTitle:59例Castleman病患者的临床病理特征及诊治分析
- Author:
Juan WANG
1
;
Lijie LIANG
;
Yaomei WANG
;
Zhenyang MEI
;
Yuzhang LIU
;
Li’na LIU
;
Baijun FANG
;
Yongping SONG
Author Information
1. 郑州大学附属肿瘤医院，河南省肿瘤医院血液科，郑州 450008
- Keywords:
Castleman disease;
Clinicopathologic features;
Treatment;
Prognosis
- From:
Chinese Journal of Hematology
2020;41(8):666-670
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathologic features, treatment, and prognosis in patients with Castleman disease (CD) .Methods:We retrospectively analyzed the clinicopathologic data of 59 patients for whom a diagnosis of Castleman disease was confirmed using pathological examination from October 2011 to October 2019 at the Henan Cancer Hospital. The patients were divided into the following two groups as per the following clinical classifications: unicentric CD (UCD, n=47) and multicentric CD (MCD, n=12) . Data on clinical manifestations, laboratory findings, treatment, and prognosis were analyzed. Results:There was no significant difference in the median age and the ratio of male to female between the UCD and MCD. UCD was characterized by asymptomatic enlargement of the single lymph node. The main pathological type was hyaline vascular histopathology (83.0%) . Of these, 44 patients chose surgical resection, and their prognosis was good. Treatment. MCD was characterized by multiple enlarged superficial and/or deep lymph nodes with B symptoms, weakness, and hepatosplenomegaly. Anemia, hypoproteinemia, and globulin level were increased on laboratory examinations. Plasmacyte histopathology was the main pathological type and was present in about 50.0% of the subjects. Only chemotherapy was performed for these MCD patients, followed by chemotherapy or chemotherapy followed by radiotherapy, and the efficient was 58.3% (7/12) .Conclusions:UCD, characterized by asymptomatic enlargement of the single lymph node, shows good postoperative prognosis. MCD has relatively complex clinical manifestations and poor prognosis, and optimal treatment is yet to be established.
