Modafinil Effect in Psychostimulant-Inapplicable Children with Attention Deficit Hyperactivity Disorder - Preliminary Study.
- Author:
Hanik K YOO
1
;
Jin Yong KIM
;
Subin PARK
;
Jeongwon JEON
;
Hee Ryung WANG
;
Boong Nyun KIM
;
Jin Pyo HONG
;
Seong Yoon KIM
;
Chang Yoon KIM
Author Information
1. Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. hiyoo@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
ADHD;
Modafinil
- MeSH:
Alopecia;
Appetite;
Attention Deficit Disorder with Hyperactivity*;
Child*;
Humans;
Parents;
Reaction Time;
Research Personnel;
Sleep Initiation and Maintenance Disorders
- From:Journal of Korean Neuropsychiatric Association
2006;45(6):598-603
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was aimed to examine the efficacy and safety of modafinil in psychostimulant-inapplicable children with attention deficit hyperactivity disorder (ADHD) due to insufficient treatment response or intolerable adverse effects. METHODS: Fifteen children (8.8+/-1.8 years, 14 boys, total IQ 107.22+/-13.4) were recruited for this study. ADHD was confirmed by K-SADS-PL. The efficacy was assessed by ADHD rating scale (ADHDRS), Conner's parental rating scale-revised (CPRS-R), ADHDRS school version, clinical global impression (CGI) and computerized neurocognitive function test. Mean dose of modafnil was 250. 0+/-103.3 mg. RESULTS: Total score (p=0.012) and hyperactive/impulsive score (p=0.021) of ADHDRS for investigator, as well as CPRS-R score (p<0.01) and CGI-severity score (p<0.01) were significantly reduced after 39.2+/-8.7 days of modafinil administration. Response time of word color test was also significantly decreased after medication. Decreased appetite (2 subjects), insomnia (2 subjects), irritability (1 subject) and alopecia (1 subject) were observed during this study period. CONCLUSION: Modafinil was effective and well-tolerated for the psychostimulant-inapplicable children with ADHD.
