A pediatric-inspired regimen for adolescents and young adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: results from a single center
10.3760/cma.j.issn.0253-2727.2020.05.007
- VernacularTitle:类似儿童方案治疗Ph染色体阴性青少年及年轻成人急性淋巴细胞白血病：一项单中心回顾性研究
- Author:
Jun FENG
1
;
Lu ZHANG
;
Xinxin CAO
;
Yan ZHANG
;
Chen YANG
;
Huacong CAI
;
Miao CHEN
;
Wei WANG
;
Wei ZHANG
;
Tienan ZHU
;
Minghui DUAN
;
Jian LI
;
Daobin ZHOU
Author Information
1. 中国医学科学院、北京协和医学院北京协和医院血液内科，北京 100730
- Keywords:
Leukemia, lymphoblastic, acute;
Adolescents;
Young adults;
Philadelphia chromosome-negative
- From:
Chinese Journal of Hematology
2020;41(5):399-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of using a pediatric-inspired regimen for adolescents and young adults (AYA) with Philadelphia chromosome-negative (Ph -) acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL) at a single center in China. Methods:Clinical data of 71 consecutive newly diagnosed AYA patients with Ph - ALL/LBL on a pediatric-inspired regimen in Peking Union Medical College Hospital from January 2012 to November 2018 were retrospectively analyzed. Results:Median age at diagnosis was 20 years (range: 15-38) , and 46 patients (64.8%) were male. Forty-nine (69.0%) had B-ALL/LBL. Among 62 ALL patients, 22 (35.5%) were high-risk. Complete remission rate was 93.0%. At follow-up with a median time of 44 months, the estimated 5-year disease-free survival (DFS) and overall survival (OS) was 56.3% and 64.3%, respectively. There was no significant difference in 5-year OS between allogeneic hematopoietic stem cell transplantation group and the continuous chemotherapy group after completion of 4 courses of chemotherapy. The 5-year DFS and OS for the non-high-risk group was 63.1% and 73.7%, respectively, which were significantly higher than 32.0% and 44.4% for the high-risk group, respectively ( P<0.001) . Conclusions:The use of pediatric-inspired regimen for AYAs with Ph - ALL/LBL was feasible and effective.
