Clinical and laboratory characteristics in patients with myeloid neoplasms complicated with clonal T large granular lymphocyte proliferation
10.3760/cma.j.issn.0253-2727.2020.04.003
- VernacularTitle:髓系肿瘤合并克隆性T大颗粒淋巴细胞增殖的临床及实验室特征
- Author:
Yin SHI
1
;
Yuanyuan LI
;
Yan LIU
;
Bin ZHENG
;
Lei SHANG
;
Qinghua LI
;
Yujiao JIA
;
Wanchen SUN
;
Zhongchao DUAN
;
Dashui HE
;
Guiqing GUO
;
Kun RU
;
Jianxiang WANG
;
Zhijian XIAO
;
Huijun WANG
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所），实验血液学国家重点实验室，国家血液系统疾病临床医学研究中心，天津 300020
- Keywords:
T large granular lymphocyte;
Clonal proliferation;
Myeloid neoplasms
- From:
Chinese Journal of Hematology
2020;41(4):276-281
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical manifestations and laboratory features in patients with myeloid neoplasms complicated with clonal T large granular lymphocyte (T-LGL) proliferation.Methods:The clinical data of 5 patients with myeloid neoplasms complicated with clonal T-LGL proliferation from November 2017 to November 2018 in Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College were analyzed retrospectively.Results:The median age was 60 years old. All patients had a history of abnormal peripheral blood cell counts for over 6 months. The absolute lymphocyte count in peripheral blood was less than 1.0×10 9/L. In addition to the typical T-LGL phenotype, the immunophenotype was heterogenous including CD4 +CD8 - in 2 patients, the other 3 CD4 -CD8 +. Four patients were αβ type T cells, the other one was γδ type. STAT3 mutation was detected in 1 patient by next-generation sequencing, the other 4 cases were negative. Conclusions:Clonal T-LGL proliferation with myeloid neoplasm develops in an indolent manner, mainly in elderly patients. Hemocytopenia is the most common manifestation. The diagnosis of T-LGL proliferation does not have specific criteria, that it should be differentiated from other T cell proliferative disorders, such as T-cell clones of undetermined significance. STAT3 or STAT5b mutation may help distinguish.
