Relationship of Neurocognitive Function with the Sleep-Wake Rhythm in Mild Cognitive Impairment Patients.
- Author:
Kyung Jin AN
1
;
Tae Hui KIM
;
Seong Jae KIM
;
Jin Hyeong JHOO
;
Jung Hie LEE
Author Information
1. Department of Psychiatry, Kangwon National University College of Medicine, Chuncheon, Korea. jhielee@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
MCI;
Sleep-wake rhythm;
Neurocognitive function
- MeSH:
Actigraphy;
Aged;
Alzheimer Disease;
Circadian Rhythm;
Humans;
Memory;
Mild Cognitive Impairment;
Polymethacrylic Acids
- From:Journal of Korean Neuropsychiatric Association
2009;48(6):447-453
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: We compared the parameters of the sleep-wake rhythm in mild cognitive impairment (MCI) patients to those of normal elderly subjects, to illustrate how the characteristics of circadian rhythm relate to a specific neurocognitive function. METHODS: We selected 12 MCI patients and 12 age- and sex-matched normal control (NC) subjects and administered the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K) Neuropsychological battery and Stroop Color-Word Test (SCWT) to each subject. We measured each subject's sleep-wake rhythm by applying actigraphy for 96 hours. The sleep-wake rhythm was examined by cosinor analysis. RESULTS: There was no significant difference in the amplitude or acrophase of the sleep-wake rhythms between the NC and MCI groups. In the combined group, amplitude was positively correlated with Constructional Praxis scores (r=0.434, p<0.05), and acrophases tended to be positively correlated with Word List Memory scores (r=0.370, p=0.07). CONCLUSION: There was no difference between MCI patients' sleep-wake rhythm's amplitude and acrophase and those of NC subjects. Furthermore, decreased amplitude was associated with impaired visuospatial function in the combined group. It will be necessary to confirm this result in an expanded MCI group in a future study.
