The clinical characteristics and outcomes of 16 Burkitt's lymphoma with testicular involvement
10.3760/cma.j.issn.0253-2727.2016.09.007
- VernacularTitle:16例伴有睾丸侵犯的伯基特淋巴瘤患儿的临床特征及疗效分析
- Author:
Shuang HUANG
1
;
Ling JIN
;
Jing YANG
;
Yanlong DUAN
;
Meng ZHANG
;
Chunju ZHOU
;
Yonghong ZHANG
Author Information
1. 100045,首都医科大学附属北京儿童医院血液肿瘤中心
- Keywords:
Burkitt lymphoma;
Testicular neoplasms;
Child;
Antineoplastic combined chemotherapy protocols
- From:
Chinese Journal of Hematology
2016;37(9):768-773
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features and outcomes of Burkitt lymphoma with testicular involvement and study the efficiency of high dose methotrexate (HD-MTX:5-8g/m2) in those patients without radiation therapy.Method Retrospective analysis was conducted in 16 Burkitt's lymphoma cases with testicular lymphoma involvement between Jan 2009 and Dec 2014.We followed the BCH-NHL-2009 protocol,modified from FAB LMB 89 combined with rituximab.All patients were enrolled in high-risk group (treated by Group C protocol).Results Of 137 Burkitt iymphoma,16 (11.67％) had testicular involvement.All the patients were in stage Ⅳ,the median age was 6.65 years (ranges:2.25 to 13.5 years).8 cases had bone marrow involvement,9 with central nervous system involvement,5 with bi-testicular involvement,1 with EB virus infection (EBV-IgM+).The median followup was 31.8 months (ranges:0.5 to 79 months).During the study period,2 cases died,1 due to the disease relapse,the other one due to chemo-related dead.1 had disease relapse 32 months after off treatment;the other 13 cases were all event free survival.3-year OS was 87.5％,3-year EFS was 72.9％.We also found the level of testosterone in ten adolescent were normal before and after chemotherapy.Conclusion For the Burkitt lymphoma with testicular involvement,we abandon radiotherapy,and administer HD-MTX to lower the toxicity.The short-term survival is better,long-term survival still needs to be clarified.
