Analyzing the correlation between endoscopic ultrasound features and immunohistochemical results of gastric stromal tumors with different risk levels
10.3969/j.issn.1672-2159.2024.03.006
- VernacularTitle:分析不同危险度胃间质瘤超声内镜特征及免疫组化结果的相关性
- Author:
Lu-Lu WANG
1
;
Rong-Hui SHI
;
Na DONG
;
Jie FENG
;
Xiao-Jun HUANG
Author Information
1. 730000 兰州大学第二临床医学院
- Keywords:
Gastric stromal tumor;
Hazard level;
Endoscopic ultrasound features;
Immunohistochemistry
- From:
Modern Interventional Diagnosis and Treatment in Gastroenterology
2024;29(3):281-286,291
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between endoscopic ultrasound features and immunohistochemical results of gastric stromal tumors at different risk levels,and provide reference for clinical diagnosis and treatment.Methods Retrospective collection of relevant indicators of gastric stromal tumor patients who received concurrent surgical treatment at Lanzhou University Second Hospital from January 2018 to July 2023,and analysis of differences in risk levels.Results The average age of onset of gastric stromal tumors was(56.02±10.94)years old,and the initial symptom of black stool was significant for different grades of gastric SMTs.Patients with different risk levels also received significant differences in treatment methods(P＜0.05).There was no difference in the classification of risk levels among the four groups of extremely low risk,low risk,medium risk,and high risk in terms of location,origin level,boundary,echo,presence or absence of cystic changes,calcification,or blood flow signals(P＜0.05);Tumor size,growth pattern,shape,internal echo uniformity,and appearance are significant factors for postoperative risk grading of gastric stromal tumors(P＜0.05).Multivariate logistic regression showed that tumor size is an independent influencing factor(P＜0.05).The immunohistochemical results showed that the positivity of DOG-1,CD34,SMA,and Desmin had no effect on the postoperative risk grading of gastric SMTs(P＜0.05);The positive expression of Vimentin,Ki-67 index,and mitosis were significantly correlated with risk(P＜0.05).Conclusion The different invasion grades of gastric stromal tumors are related to the size,shape,and echo of the lesion.Endoscopic ultrasound can effectively diagnose gastric stromal tumors,and combining with immunohistochemical related indicators can better evaluate the overall condition of patients with gastric stromal tumors,providing reference for clinical diagnosis and treatment.
