Expression levels of miR-934 and miR-1307 in serum of patients with esophageal squamous cell carcinoma and their relationship with clinicopathological features and prognosis
10.3969/j.issn.1672-2159.2024.02.008
- VernacularTitle:miR-934和miR-1307在食管鳞癌患者血清中的表达水平及与临床病理特征和预后的关系
- Author:
Zhuo LIU
1
;
Zheng ZHAO
;
Liang-Liang ZHANG
;
Zhao JIN
Author Information
1. 056000 邯郸市中心医院西区胸外一科
- Keywords:
Esophageal squamous cell carcinoma;
Microribonucleic acid-934;
Microribonucleic acid-1307;
Clinicopathological features;
Prognosis
- From:
Modern Interventional Diagnosis and Treatment in Gastroenterology
2024;29(2):158-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the expression levels of miR-934 and miR-1307 in serum of patients with esophageal squamous cell carcinoma(ESCC),and analyze the relationship between their expression and clinicopathological features and prognosis.Methods A total of 125 ESCC patients(ESCC group)who were admitted to our hospital from January 2018 to December 2019 were selected,and 100 healthy subjects(control group)were selected during the same period,the expression of miR-934 and miR-1307 in serum were detected by real-time fluorescence quantitative reverse transcription polymerase chain reaction(qRT-PCR).After 3 years of follow-up,the patients were divided into miR-934 low expression group(＜2.53)and miR-934 high expression group(≥2.53),miR-1307 low expression group(＜2.10)and miR-1307 high expression group(≥2.10),based on their mean values,the prognosis of patients with different expression of miR-934 and miR-1307 in serum was compared,and the related factors affecting the survival and prognosis of patients were analyzed by univariate and multivariate COX regression analysis.Results The relative expression levels of serum miR-934 and miR-1307 in ESCC group were 2.53±0.72 and 2.10±0.68 respectively,significantly higher than those in control group's 1.32±0.39 and 1.12±0.33(all P＜0.05).Serum miR-934 and miR-1307 were closely related to TNM stage,lymph node metastasis,tumor differentiation and distant metastasis in ESCC patients(all P＜0.05).The 3-year progression-free survival(PFS)in serum miR-934 and miR-1307 high expression group was lower than that in miR-934 and miR-1307 low expression group.Multivariate Cox regression analysis showed that,TNM stage Ⅲ～Ⅳ,high expression of miR-934 and high expression of miR-1307,low differentiation degree and distant metastasis were independent risk factors for PFS in ESCC patients(all P＜0.05).Conclusion Serum miR-934 and miR-1307 are abnormally highly express in ESCC patients,and their high expression is an independent risk factor for poor prognosis of ESCC patients,which is expected to be a marker for prognosis evaluation of ESCC.
