Chromosome t(8;21) and t(15;17) in a patient with acute myeloid leukemia
10.3760/j:issn:0253-2727.2001.02.010
- VernacularTitle:同时具有染色体t(8;21)和t(15;17)的急性白血病一例
- Author:
Yanrong GAO
1
;
Chun WANG
;
Lan XU
Author Information
1. Shanghai First People Hospital
- From:
Chinese Journal of Hematology
2001;22(2):94-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report an acute myeloid leukemia (AML) patient with both chromosome t(8;21) a nd t(15;17). Methods Chromosome specimen was prepared by short-t erm culture of bone marrow cells, karyotype analyses by R-banding technique, an d fusion genes by reverse transcriptase-polymerase chain reaction (RT-PCR). Result Karyotype analyses showed the appearance of 45, X, -X,t(8;21 ),t(15;17), and RT-PCR assay revealed AML1/ETO and PML-RARα fusion gene tran scripts. Conclusion AML with both t(8;21) and t(15;17) might be r ecognized as a a novel subtype of acute leukemias.
