Combination of mycophenolate mofetil with cyclosporine A and methotrexate as acu te GVHD prophylaxis after unrelated donor allogeneic bone marrow transplantation
10.3760/j:issn:0253-2727.2001.02.005
- VernacularTitle:霉酚酸酯联合CsA和短程MTX预防非亲缘异基因骨髓移植的急性GVHD
- Author:
He HUANG
1
;
Maofang LIN
;
Haitao MENG
Author Information
1. 浙江大学附属第一医院
- From:
Chinese Journal of Hematology
2001;22(2):76-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of mycophenolate mofetil（MMF） in combinat ion with cyclosporine A(CsA) and methotrexate(MTX) for prevention of acute graft versus host disease(GVHD) after unrelated donor allogeneic bone marrow transpla ntation (allo-BMT). Method Twelve cases of unrelated donor allo -BMT were evaluated in a single center trial. The acute GVHD was prevented with 1 g MMF daily in addition to CsA 3?mg*kg-1*d-1 and MTX 10～15 ?mg at post BMT day1，day3，day6 and day11. Results Acute GVHD was found in one case（Grade Ⅳ） at the seventh day and two cases （Grade Ⅱ ）at the tenth day and seventeenth day after BMT. These patients were treated wi th a combination of MMF,methyprednisolone and CsA. The common adverse hematologic events of MMF was leukopenia. Conclusion The preliminary study showed that MMF could be used effectively and safe ly for prevention of acute GVHD in unrelated donor allo-BMT.
