Neutrophil and burn sepsis

VernacularTitle:中性粒细胞与烧伤脓毒症
Author: Bingwei SUN ¹ ; Yifan WANG ; Yunxi YANG
Author Information

1. 南京医科大学附属苏州医院烧伤整形科，苏州　215002
Keywords: Burns; Sepsis; Neutrophil; Mechanism; Early warning
From: Chinese Journal of Burns 2024;40(7):618-624
CountryChina
Language:Chinese
Abstract: Sepsis is the most common complication of severe burns and a primary risk factor for endangering the lives of critically severe burn patients. The mortality rate of burn sepsis patients was up to 75%. Neutrophils are one of the innate immune cells and are the earliest and most recruited immune cells at the site of infection, which play a key role in the removal of local infection and the repair of damaged tissue. Many studies have deeply revealed the pathogenesis and progression mechanism of burn sepsis, in which the role of neutrophils has gradually become clear. This paper elaborated on the key mechanisms of neutrophils in the occurrence and evolution of burn sepsis, explored the value of neutrophils in the early warning and prognosis judgement, and the potential therapeutic methods of burn sepsis based on the unique biological behavior of neutrophils in burn sepsis.