Ilizarov bone transport combined with antibiotic bone cement promotes junction healing of large tibial bone defect
- VernacularTitle:Ilizarov骨搬移联合抗生素骨水泥促进胫骨大段骨缺损的对接点愈合
- Author:
Zhibo ZHANG
1
;
Zhaolin WANG
;
Zhigang WANG
;
Peng LI
;
Jianhao JIANG
;
Kai ZHANG
;
Shuye YANG
;
Gangqiang DU
Author Information
- Keywords: membrane induction osteogenesis technique; bone transport; docking site; bone healing; open tibial fracture; large-segment bone defect
- From: Chinese Journal of Tissue Engineering Research 2025;29(10):2038-2043
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Ilizarov bone transport is very effective in the treatment of open large tibial bone defects,but there are still complications,among which the difficulty of junction healing is one of the difficult points in treatment. OBJECTIVE:To investigate the effect of Ilizarov bone transport combined with antibiotic bone cement on junction healing after operation of open large tibial bone defect. METHODS:Totally 51 patients with open large tibial bone defect(bone defect>4 cm)admitted to Binzhou Medical University Hospital from August 2010 to January 2022 were selected,of which 28 received Ilizarov bone transport alone(control group)and 23 received Ilizarov bone transport combined with antibiotic bone cement treatment(trial group).External fixation time,bone healing time,bone healing index,visual analog scale score during bone removal,bone defect limb function,junction healing and complications at the final follow-up were statistically compared between the two groups. RESULTS AND CONCLUSION:(1)All the 51 patients were followed up for a mean of(22.53±5.77)months.External fixation time,bone healing time,bone healing index,postoperative infection rate,and non-healing rate of junction were less in the trial group than those in the control group(P<0.05).There was no significant difference between the two groups in visual analog scale scores at 6 months after the second surgery and in the functional excellence and good rate of limb with bone defect at the final follow-up(P>0.05).(2)These findings indicate that compared with the Ilizarov bone transport alone,Ilizarov bone transport combined with antibiotic bone cement treatment can promote the healing of open tibial fracture junction and increase the rate of bone healing.
