24 hour circadian pattern of blood pressure and its related target organ damage in hypertensive subjects.
- Author:
Chang Keun CHOI
1
;
Kwang Sik YOON
;
Do Ho MOON
;
Byung Jin AHN
;
Seung Bock LEE
;
An Chul JEONG
;
Sung Kyoung DOH
;
Hyun Jin KWAK
;
Yong Hoon KIM
;
Hong Soon LEE
;
Soo Woong YOO
Author Information
1. National Medical Center Internal medicine.
- Publication Type:Original Article
- Keywords:
Dipper;
Non-dipper;
Target organ damage
- MeSH:
Blood Pressure Monitoring, Ambulatory;
Blood Pressure*;
Creatinine;
Electrocardiography;
Heart Failure;
Humans;
Hypertension;
Hypertension, Renovascular;
Hypertensive Retinopathy;
Hypertrophy;
Physical Examination;
Prospective Studies;
Proteinuria;
Stroke;
Thorax
- From:Korean Journal of Medicine
1998;55(1):52-58
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Pattern with essential hypertension generally shows the same circadian pattern as the normothensive person with a night-time reduction or "DIP" in blood pressure in sleep. The definition of "Dipper" and "Non-dipper" are assigned according to arbitrary criteria e.g. a night time average blood pressure which is at least 10% less than the average daytime blood pressure. Prospective evidence that the absence of an overnight dip is a strong adverse prognostic indicator for target organ damage .Thus we investigate circardian rhythm of blood pressure, related target organ damage, its frequency & drug in hypertensive subjects. Method : 24hr ambulatory blood pressure monitoring, history taking, physical examination, fundoscopy, ECG, chest X ray, dipstick urinanlysis, serum creatinine level are performed in essential hypertensive subjects. Exclusion criteria are duration of hypertension over 5 years, DM, renovascular hypertension & heart failure. RESULTS: Total 42 patients performed study.17 subjects classify dipper group,25 subjects classify non-dipper group. Between dipper & non-dipper group shows no significantly difference at stroke history, C/T ratio over 0.5 in chest X-ray, left ventrcular hypertrophy in ECG,ST-T change in ECG, proteinuria & serum creatinine level. Non-dipper group shows significantly difference to dipper group in frequency of hypertensive retinopathy and number of combined drug used subjects. CONCLUSION: Number of hypertensive retinopathy is significantly frequency in non-dipper group. Hypertensive retinopathy is atherosclerotic complication, thus we predict other target organ damage, therefore non-dipper type circardian rhythm of blood pressure is adverse prognostic factor for target organ damage of hypertensive subjects.
